Cabozantinib (XL184，BMS-907351) cas:849217-68-1

Cabozantinib (XL184,BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met,Ret,Kit,Flt-1/3/4,Tie2,and AXL with IC50 of 1.3 nM,4 nM,4.6 nM,12 nM/11.3 nM/6 nM,14.3 nM and 7 nM in cell-free assays, respectively.Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.

msds---Cabozantinib (XL184，BMS-907351)